Aminoacetaldehyde dimethyl acetal → HCID 20605658, compound

Participants

Reaction Steps

In a round bottom flask are 4-Methylsulfanyl-1-[2-(4-nitro-phenyl)-ethyl]-6,7-dihydro-1H-pyrrolo[3,2-C]pyridine-3-carboxylic acid methyl ester (25.33 mmol), amino acetaldhyde dimethyl acetal (63.32 mmol) and 125 mL MeOH combined (a part “oiled-out” that later went into solution) and stirred at RT for 20 hours. The solvent is evaporated in vacuo yielding 4-(2,2-Dimethoxy-ethylamino)-1-[2-(4-nitro-phenyl)-ethyl]-6,7-dihydro-1H-pyrrolo[3,2-c]pyridine-3-carboxylic acid methyl ester, 11.56 g, as a yellow oil/solid that is used without purification.

Provenance & Evidence