Potassium Hydroxide → 6-Benzyloxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic Acid

Participants

Reaction Steps

A solution of 6-benzyloxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid benzyl ester (30) (1 equi.) and potassium hydroxide (3.5 equi.) in water-ethanol (1:1) (25 mL/mmole) was stirred at 80 C temperature for 2 h, cooled to room temperature, and quenched with hydrochloric acid (5%), the resulting white solid was filtered, washed with water, and dried under vacuum to give 6-benzyloxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid (31) as a white solid (95%).

Provenance & Evidence