HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxybenzaldehyde → (2RS)-2-benzyl-1-(2,5-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxybenzaldehyde | HCID 11569 | — |
| Reactant | 2,5-Dichlorobenzaldehyde | HCID 80702 | — |
| Reactant | (2RS)-2-benzyl-1-(2,4-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride | HCID 18767270 | — |
| Product | (2RS)-2-benzyl-1-(2,5-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride | HCID 18767286 | — |
Reaction Steps
The synthesis was carried out according to the procedure of Example 1, except that 5.0 g (0.028 mole) of 2,5-dichlorobenzaldehyde were used instead of 3-methoxybenzaldehyde. The reaction steps involving Grignard reaction, oxidation and Mannich reaction led to a total yield of 1.4 g (14%) of (2RS)-2-benzyl-1-(2,4-dichlorophenyl)-3-dimethylaminopropan-1-one hydrochloride with a melting point of 140° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06653508B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-207ef4f9f5a64ae1989bb39099596136 |
| Source note | uspto-grants-2003_11 |