HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cinnamoylbenzene → (2RS)-(3RS)-2-dimethylaminomethyl-1,3-diphenyl-3-p-tolylpropan-1-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cinnamoylbenzene | HCID 7189 | — |
| Reactant | 4-Bromotoluene | HCID 7805 | — |
| Reactant | Dimethyl(methylene)ammounium iodide | HCID 2724133 | — |
| Reactant | (2RS)-(3RS)-2-dimethylamino-methyl-1,3-diphenyl-3-p-tolylpropan-1-one hydrochloride | HCID 70010556 | — |
| Product | (2RS)-(3RS)-2-dimethylaminomethyl-1,3-diphenyl-3-p-tolylpropan-1-one hydrochloride | HCID 18767264 | — |
Reaction Steps
The synthesis was carried out according to the procedure of Example 38 and the chalcone derivative was reacted with 4-bromotoluene. The Eschenmoser salt was then added in an equimolar amount. The yield of (2RS)-(3RS)-2-dimethylamino-methyl-1,3-diphenyl-3-p-tolylpropan-1-one hydrochloride was 0.7 g (41%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06653508B2 |
| Source dataset | uspto-grants-2003_11 |
| ORD ID | ord-2f51a961d21b4628bd9082de9c1ccc62 |
| Source note | uspto-grants-2003_11 |