Methanol → HCID 22672527, 화합물

참여 물질

역할	이름	HCID	투입량
반응물	Methanol	HCID 887	—
반응물	Triethylamine	HCID 8471	—
반응물	2-Cyanoethyl N,N-diisopropylchlorophosphoramidite	HCID 2734844	—
반응물	8-(3-Hydroxypropyl)-7-oxophenoxazin-3-yl 2,2-dimethylpropanoate	HCID 22672525	—
용매	Diethyl Ether	HCID 3283	—
용매	Dichloromethane	HCID 6344	—
용매	Hexane	HCID 8058	—
생성물	HCID 22672527	HCID 22672527	—

반응 단계

36b (0.38 g, 1.1 mmol) was dissolved in 6 mL of anhydrous CH2Cl2. Triethylamine (1.5 mL) was added followed by 2-cyanoethyl diisopropylchlorophosphoramidite (0.29 mL, 1.3 mmol). The solution was kept at room temperature for 30 min, MeOH (0.1 mL) was added and the reaction was concentrated under vacuum. The residue obtained was partitioned between ethyl acetate and NaHCO3. The organic phase was washed with saturated NaCl, dried over Na2SO4 and concentrated to afford the crude amidite. It was dissolved in 2 mL of ether and added dropwise to ˜50 mL of hexane. The resultant orange solid was collected by filtration, washed with hexane and dried. The yield was 0.4 g.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06653473B2
출처 데이터셋	uspto-grants-2003_11
ORD ID	ord-c857989af4fc4ad09c4bff79852c8fa4
출처 메모	uspto-grants-2003_11