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3,4-dihydro-2H-pyran → 2-[(10-Bromodecyl)oxy]tetrahydro-2H-pyran
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | 1-Decanol, 10-bromo- | HCID 104507 | — |
| 触媒 | Pyridine | HCID 1049 | — |
| 触媒 | Silanol, trimethyl-, 1,1'-sulfate | HCID 87573 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-[(10-Bromodecyl)oxy]tetrahydro-2H-pyran | HCID 103543 | 42.8% |
反応手順
A mixture of 100 g 1-bromodecan-10-ol, 2.1 g bis(trimethylsilyl)sulphate, 43 g 3,4-dihydro-2H-pyran and 500 ml dichloromethane is stirred for 6 hours at room temperature. Several drops of pyridine are added and the reaction mixture evaporated down. The residue is purified by column chromatography on silica gel using hexane/ethyl acetate (1/1 v/v) as eluent to yield 58 g of 1-bromo-10-[tetrahydropyranyloxy]decane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06653499B1 |
| 出典データセット | uspto-grants-2003_11 |
| ORD ID | ord-270d3152095d4875925be10b4e5aff8a |
| 出典メモ | uspto-grants-2003_11 |