1-(2-Methoxyphenyl)piperazine → HCID 19066133, compound

Participants

Reaction Steps

In triethylamine (3 ml)-dioxane (80 ml) were dissolved 2.4 g of methyl 4-bromomethylphenylacetate and 1.9 g of 1-(2-methoxyphenyl)piperazine and the solution was stirred at room temperature for 4 hours. The solvent was then distilled off and the residue was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous sodium sulfate, and the solvent was distilled off. The residue was purified by column chromatography [silica gel, hexane-ethyl acetate=2:1] and the resulting oil was refluxed in a mixture of 30 ml 2N-sodium hydroxide and 10 ml methanol for 3 hours. The solvent was then distilled off and the residue was dissolved in water and filtered. The filtrate was neutralized with acetic acid and extracted with chloroform. The solvent was then distilled off and the residue was recrystallized from methanol-ethylether to provide 2.0 g of the title compound melting at 87° C.-90° C. The IR absorption spectrum of this product is presented in FIG. 2.

Provenance & Evidence