Hydrochloric Acid → 4-[[4-(2-Tolyl)-1-piperazinyl]methyl]phenylacetic acid hydrochloride

Participants

Reaction Steps

Using 2.2 g of methyl 4-bromomethylphenylacetate, 1.9 g of 1-(2-tolyl)piperazine hydrochloride, 2.5 ml of triethylamine, and 80 ml of dioxane, the reaction procedure of Example 2 was otherwise repeated and the reaction product was converted to the hydrochloride using 2N-hydrochloric acid and recrystallized from ethanol-ether to provide 1.7 g of the title compound melting at 249° C.-252° C.

Provenance & Evidence