HCID 86752957, compound → HCID 14988922, compound

Participants

Reaction Steps

A solution of 6-cyclohexylcarbamoyloxy-4-[3-(3-ethoxycarbonyl-2-propenyl)-2-methyloxiranyl]-5-methoxy-1-oxaspiro[2,5]octane (46 mg) in ethyl acetate (30 ml) was hydrogenated under hydrogen (1 atm) in the presence of platinum oxide (5 mg) for 2 hours. The catalyst was removed by filtration and the filtrate was concentrated in vacuo. The residue was purified by column chromatography on silica gel eluted with a mixture of diethyl ether and n-hexane (1:1) to give 6-cyclohexylcarbamoyloxy-4-[3-(3-ethoxycarbonylpropyl)-2-methyloxiranyl]-5-methoxy-1-oxaspiro[2,5]octane as an oil.

Provenance & Evidence