HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4,6-Trimethylaniline → 1-(2,4,6-Trimethylphenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4,6-Trimethylaniline | HCID 6913 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 1-(5,6,7,8-Tetrahydronaphthalen-1-yl)piperazine | HCID 98698 | — |
| Reactant | Bis(2-chloroethyl)amine hydrochloride | HCID 522769 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 1-(2,4,6-Trimethylphenyl)piperazine | HCID 2760822 | 55% |
Reaction Steps
Compound 31A is prepared according to the procedure described for compound 26A, using the following reactants: 2,4,6-trimethylaniline (4.8 ml, 34 mmol); bis(2-chloroethyl)amine hydrochloride (6.05 g, 34 mmol); sodium carbonate (1.8 g, 17 mmol); 1-butanol (75 ml). After impregnating onto silica, the crude reaction product is purified by flash chromatography with a mixture (95/5/1) and then (90/9/1) of dichloromethane/methanol/aqueous ammonia.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789412 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-7551cec5b6054c4e8f02f722f5cf9e8e |
| Source note | uspto-grants-1998_08 |