Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Aminophenol | HCID 5801 | — |
| Reactant | Nitrogen mustard hydrochloride | HCID 5935 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | o-(1-Piperazinyl)phenol | HCID 70530 | — |
Reaction Steps
2-Aminophenol (6 g; 54 mmol) is dissolved in 1-butanol (110 ml) in the presence of sodium carbonate (2.9 g; 27.5 mmol) and N-methylbis(2-chloroethyl)amine hydrochloride (11.1 g; 58 mmol). The suspension is heated at 123° C. for 3 days. The butanol is evaporated off under reduced pressure and compound 43A is purified by flash chromatography with the following mixtures of eluents: NH4 OH/acetone/CH2Cl2 (0.5/20/80) and then NH4 OH/methanol/CH2Cl2 (1/5/95).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05789412 |
|---|
| Source dataset | uspto-grants-1998_08 |
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| ORD ID | ord-76dea39994dd46e599c409f42727a191 |
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| Source note | uspto-grants-1998_08 |
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