HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitrogen mustard hydrochloride → 4-Chloro-2-(1-piperazinyl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitrogen mustard hydrochloride | HCID 5935 | — |
| Reactant | 2-Amino-4-chlorophenol | HCID 7265 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | o-(1-Piperazinyl)phenol | HCID 70530 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 4-Chloro-2-(1-piperazinyl)phenol | HCID 23447881 | — |
Reaction Steps
The derivative 45A is prepared according to the same procedure described for 43A, using the following reactants: 2-amino-4-chlorophenol (3 g; 20.9 mmol); N-methylbis(2-chloroethyl)amine hydrochloride (4.2 g; 22 mmol); sodium carbonate (1.1 g; 10.5 mmol); 1-butanol (42 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789412 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-9d06eac5a3014c1e91aca10b1695f539 |
| Source note | uspto-grants-1998_08 |