HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1-Naphthyl)piperazine → 2-Chloro-1-[4-(1-naphthyl)piperazin-1-yl]ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1-Naphthyl)piperazine | HCID 1342 | — |
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | Calcium Carbonate | HCID 10112 | — |
| Reactant | 2-Chloro-1-(4-o-tolylpiperazin-1-yl)ethanone | HCID 4741212 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | 2-Chloro-1-[4-(1-naphthyl)piperazin-1-yl]ethanone | HCID 4741241 | 92% |
Reaction Steps
Compound 49A is prepared according to the procedure described for compound 12A using the following reactants: chloroacetyl chloride (270 ml, 3.45 mmol); 1-(1-naphthyl)piperazine (610 mg, 2.88 mmol); calcium carbonate (860 mg, 8.64 mmol); methyl ethyl ketone (20 ml).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789412 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-9322168791ba41ad9e780d551849caaa |
| Source note | uspto-grants-1998_08 |