5-Amino-2-naphthol → HCID 19066178, compound

HRID 481369Notes

Reaction equation

HRID 481369 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:9]=[C:10](O)[CH:11]=[CH:12][CH:13]=2)[CH2:4][CH2:3]1.NC1C=CC=[C:20]2C=1C=[CH:23][C:22]([OH:26])=[CH:21]2.C(=O)([O-])[O-].[Na+].[Na+]>C(O)CCC>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]3[C:9]=2[CH:20]=[CH:21][C:22]([OH:26])=[CH:23]3)[CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 68655-Amino-2-naphtholHCID 10340Sodium CarbonateHCID 110114553-(4-Methylpiperazin-1-yl)phenol

Product 1

HCID 19066178HCID 19066178, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

Compound 53A is prepared according to the same procedure as that for 13A, using the following reactants: 8-aminonaphthalen-3-ol (10 g, 62.8 mmol), 2-chloro-N-(2-chlorethyl)-N-methylethananine hydrochloride (11.8 g, 62.8 mmol), sodium carbonate (3.32 g, 31.4 mmol), 1-butanol (200 ml).

Sources & evidence

ORD record
ord-1bdb645bbb454864b021f0025d4551f1
Source dataset
uspto-grants-1998_08
Patent number
US05789412

Reaction notes

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