反应详情

温度

80 °C

To a solution of the product of Step 5, above (6), in methanol was added an excess of 2N NaOH. The reaction mixture was heated to 80° C. for 1 hour, cooled to room temperature and the solvent evaporated. Water was added to the residue and the solution was extracted 2 times with EtOAc. The aqueous layer was acidified with 10% HCl and the resultant white suspension was extracted 2 times with EtOAc. The organics were dried over MgSO4, filtered and concentrated to a solid. The solid was crystallized from EtOAc to yield the title compound (8).

1. temperaturecooled to room temperature
2. customthe solvent evaporated
3. additionWater was added to the residue
4. extractionthe solution was extracted 2 times with EtOAc
5. extractionthe resultant white suspension was extracted 2 times with EtOAc
6. dry with materialThe organics were dried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated to a solid
9. customThe solid was crystallized from EtOAc