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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 481396Generated: October 25, 2026

2-Cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine → 2-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]indan-2-carboxylic acid ethyl ester

https://huagongshe.com/reaction/481396

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Cyclopropyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridineHCID 10313440—
Reactant2-(5-Chloromethylthiophen-2-yl)-indan-2-carboxylic acid ethyl esterHCID 57078924—
Product2-[5-(2-Cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridin-3-ylmethyl)thiophen-2-yl]indan-2-carboxylic acid ethyl esterHCID 70083715—

Reaction Steps

The product of Example 6, Step 4, above (26), was alkylated as described in Example 1, Step 5, using 2-cyclopropyl-5,7-dimethylimidazo[4,5-b]pyridine (13) to obtain the title compound (29).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05789415
Source datasetuspto-grants-1998_08
ORD IDord-7474aaa5a7444585a58bef72af5902dc
Source noteuspto-grants-1998_08