関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Azobisisobutyronitrile | HCID 6547 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 1-(5-Methylpyridin-2-yl)cyclopentane carboxylic acid ethyl ester | HCID 57245012 | — |
| 溶媒 | Carbon Tetrachloride | HCID 5943 | — |
| 生成物 | 1-(5-Bromomethylpyridin-2-yl)cyclopentanecarboxlic acid ethyl ester | HCID 70103586 | — |
反応手順
A mixture containing the product of Step 2, above (44) (1 equiv.), n-bromosuccinimide (1.1 equiv.), CCl4 and a catalytic amount of azobisisobutyronitrile was heated at reflux for 4 hours, cooled to 0° C. and filtered through celite. The residue was washed well with CCl4 and the filtrate was concentrated and chromatographed on silica gel to yield the title compound (45).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05789415 |
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| 出典データセット | uspto-grants-1998_08 |
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| ORD ID | ord-7289d1e66d054edab6bb6e540f7037b8 |
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| 出典メモ | uspto-grants-1998_08 |
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