Sodium Hydroxide → HCID 9867367, compound

Participants

Reaction Steps

The product of Step 2, above (86) (40 mg), was dissolved in 1.0 ml of methanol and an excess of 2N NaOH (0.5 ml) was added. The reaction mixture was stirred at room temperature for 5 hours, evaporated to dryness and the residue taken up into water. The aqueous solution was extracted with ethyl acetate to remove unreacted starting material, then was acidified with acetic acid and extracted again with ethyl acetate. The EtOAc extract was dried and concentrated using heptane to azeotrope off any residual acetic acid. The resulting solid was precipitated from EtOAc/hexanes, filtered and dried under vacuum to yield the title compound (87).

Provenance & Evidence