HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl isonipecotate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Piperidinecarboxylic acid | HCID 3773 | — |
| Product | Methyl isonipecotate | HCID 424914 | — |
Reaction Steps
Isonipecotic acid 2-3a (25 g, 0.19 mol; Aldrich) was suspended in MeOH (300 mL) at room temperature and HCl gas was bubbled through until saturated and a clear solution was obtained. After a further 10 minutes, the solvent was removed in vacuo to provide 2-3b as a solid (HCl salt).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789421 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-3e077fed7003451a87f490b07f2e6b7c |
| Source note | uspto-grants-1998_08 |