HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Di-tert-butyl dicarbonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | 4-Piperidinecarboxylic acid, methyl ester, hydrochloride (1:1) | HCID 18783829 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Product | 1-N-Boc-4-Piperidinecarboxylic acid methyl ester | HCID 392870 | — |
Reaction Steps
To a solution of isonipecotic acid methyl ester HCl (2-3b) (34 g, 0.19 mol), and di-tert-butyl dicarbonate (43.5 g, 0.2 mol) in THF (300 mL) and H2O (150 mL) was added-K2CO3 (28.8 g, 0.21 mol). After 4 hours, the mixture was poured into water, extracted with EtOAc then washed with brine, dried (MgSO4) and evaporated to give the title compound 2-3c as an oil with a small amount of di-tert-butyl dicarbonate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789421 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-fc7ad82c9fb44272bc921a4008637bb6 |
| Source note | uspto-grants-1998_08 |