Propargyl bromide → HCID 19066336, compound

Participants

Reaction Steps

Using an analogous procedure to that described in the first paragraph of Example 1, N-(3-cyanobenzyl)-p-[N-((6RS)-2-methyl-4-oxo-3-pivaloyloxymethyl-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)amino]benzamide (0.36 g) was reacted with propargyl bromide to give N-(3-cyanobenzyl)-p-[N-(2-methyl-4-oxo-3-pivaloyloxymethyl-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]benzamide (0.154 g).

Provenance & Evidence