HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]pyridine-2-carboxylic acid → HCID 178456765, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]pyridine-2-carboxylic acid | HCID 135848307 | — |
| Reactant | methyl (2S)-2-amino-4-(1H-1,2,3,4-tetrazol-5-yl)butanoate | HCID 178501500 | — |
| Product | HCID 178456765 | HCID 178456765 | 33% |
Reaction Steps
Using analogous procedures to those described in Example 12, 5-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]pyridine-2-carboxylic acid was reacted with methyl (2S)-2-amino-4-(tetrazol-5-yl)butyrate to give (2S)-2-{5-[N-((6RS)-2-methyl-4-oxo-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)-N-(prop-2-ynyl)amino]pyridine-2-carboxamido}-4-(tetrazol-5-yl)butyric acid in 33% yield, m.p. 189°-191° C.;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789417 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-ae687ba1cc2c4abab105f1129ceec57f |
| Source note | uspto-grants-1998_08 |