Hydrogen Bromide → HCID 19066544, compound

Participants

Reaction Steps

To 5.81 g (14.7 mmol) of N-(4-chlorophenyl)-N'-(3-pyridylmethyl)-N'-2-(benzyloxy)ethyl urea in a 100 ml round-bottomed flask were added 65 ml of 48% hydrobromic acid at room temperature. The mixture was heated gradually and then heated for 4 hours at 95° to 100° C. The reaction mixture was cooled to room temperature, 20 ml of water were added, and further 50 ml of ethyl acetate were added to extract. The ethyl acetate layer was extracted with 30 ml of 6N hydrochloric acid, which was combined with previous aqueous layer. While cooling this with ice, pH was made to be 12 or higher with potassium hydroxide and extracted thrice with 100 ml of methylene chloride. The organic layers were combined, dried over anhydrous sodium sulfate, and then solvent was distilled off under reduced pressure to obtain 2.28 g (yield 54%) of 1-(4-chlorophenyl)-3-(3-pyridylmethyl)-2-imidazolidinone as brown crystals.

Provenance & Evidence