4-Phenylbutyric Acid → 4-phenylbutyrylamino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one

참여 물질

반응 단계

A few drops of dimethylformamide and then, dropwise, 2.8 ml of thionyl chloride are added to 5 g of 4-phenylbutyric acid, in solution in 60 ml of anhydrous dichloromethane, at a temperature in the region of 20° C. After reacting overnight at the same temperature, the reaction mixture is concentrated to dryness under reduced pressure. The chloride of 4-phenylbutyric acid thus prepared is added dropwise to 1 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one, in solution in 75 ml of dimethylformamide, at a temperature in the region of 20° C. The reaction mixture is heated at reflux for 7 hours. The precipitate formed is filtered and recrystallized from dimethylformamide. After filtration, washing with water and then ethyl ether and drying under partial vacuum (1 mm Hg, 0.13 kPa) at 80° C., there is obtained 0.64 g of 8-(4-phenylbutyrylamino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one in the form of an ochre solid which decomposes at 190° C. (Analysis C23H20N4O2.0.63H2O.0.79DMF, % calculated C: 71.86, H: 5.24, N: 14.57, % found C: 71.5, H: 5.1, N: 14.8).

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