反应详情

The preparation is carried out as in Example 12, from 5 g of 5-phenylvaleric acid, 2.5 ml of thionyl chloride, 60 ml of dichloromethane, 1 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one and 75 ml of dimethylformamide. After refluxing for 7 hours, the insoluble material is filtered and recrystallized from dimethylformamide. After filtration, washing with water and drying under reduced pressure (1 mm Hg, 0.13 kPa) at 80° C., there is obtained 0.58 g of 8-(5-phenylvalerylamino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one in the form of a yellow solid which decomposes at 170° C. (Analysis C24H22N4O2.0.41DMF, % calculated C: 72.34, H: 5.56, N: 14.06, % found C: 72.0, H: 5.6, N: 13.8).

1. temperatureAfter refluxing for 7 hours
2. filtrationthe insoluble material is filtered
3. customrecrystallized from dimethylformamide
4. filtrationAfter filtration
5. washwashing with water
6. customdrying under reduced pressure (1 mm Hg, 0.13 kPa) at 80° C.