反应详情

The preparation is carried out in the same way as in Example 20, from 1 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride, 1 ml of triethylamine and 0.97 ml of 2-methoxyphenyl isocyanate. After reacting for 6 hours at a temperature in the region of 20° C., the insoluble material is filtered and washed with water and then with isopropyl ether. 0.3 g of 8-[3-(2-methoxyphenyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one are thus obtained in the form of a beige solid, the melting point of which is greater than 260° C. (Analysis C21H17N5 O3.0.76H2O, % calculated C: 65.11, H: 4.42, N: 18.08, % found C: 64.8, H: 4.3, N: 18.4).

1. filtrationthe insoluble material is filtered
2. washwashed with water