Dimethylformamide → 8-[3-(2-ethoxycarbonylethyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one

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The preparation is carried out as in Example 32 but from 4 g of 8-amino-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one hydrochloride, 86 ml of dimethylformamide, 7.3 ml of triethylamine and 4.42 g of ethyl 3-isocyanatopropionate and the reaction mixture is stirred at a temperature in the region of 20° C. for 90 hours. After evaporation of the dimethylformamide, 300 ml of water are added and the precipitate formed is filtered, washed with water (50 ml) and then with acetone (2×50 ml) and dried at 60° C. under vacuum (1 mm Hg, 0.13 kPa). There are obtained 2.1 g of 8-[3-(2-ethoxycarbonylethyl)ureido]-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one in the form of a beige solid melting above 260° C. (Analysis, % calculated C: 59.84, H: 5.02, N: 18.36, O: 16.78, % found C: 59.5, H: 5.1, N: 18.5).

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