反应详情

Methyl(4-hydroxy-3-nitrophenyl)acetate [from step 3] (48.9 g, 0.23 mole) and 5% palladium on carbon were suspended in methanol and the resulting mixture was hydrogenated until all the starting material had been consumed. The reaction mixture was filtered to remove the catalyst and the filtercake was washed with methanol. The combined filtrate and washings were concentrated in vacuo, affording methyl(3-amino-4-hydroxyphenyl)acetate as a solid (41.0 g).

1. customhad been consumed
2. filtrationThe reaction mixture was filtered
3. customto remove the catalyst
4. washthe filtercake was washed with methanol
5. concentrationThe combined filtrate and washings were concentrated in vacuo