反应详情

To a stirred solution of Compound 39 (500 mg, 3.10 mmol) and 2-Iodopropane (0.930 ml, 9.30 mmol) in acetone (8 ml) was added Cs2CO3 (4.55 g, 14.0 mmol), and refluxed for 2 h. The mixture was filtered over celite and washed with acetone. The filtrate was concentrated to give crude Compound 40. This was diluted with AcOEt, washed with water and brine, dried (MgSO4), and concentrated. This was purified by a column chromatography on silica gel to give Compound 40 (610 mg, 97%) as a colorless oil.

1. temperaturerefluxed for 2 h
2. filtrationThe mixture was filtered over celite
3. washwashed with acetone
4. concentrationThe filtrate was concentrated
5. customto give crude Compound 40
6. washwashed with water and brine
7. dry with materialdried (MgSO4)
8. concentrationconcentrated
9. customThis was purified by a column chromatography on silica gel