(2S,3S)-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidine → (2S,3S)-3-(5-(1-Cyano-1-methylethyl)-2-isopropoxybenzyl)amino-2-phenylpiperidine

HRID 481515Notes

Reaction equation

HRID 481515 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([NH:14][CH2:15][C:16]2[CH:21]=[C:20]([C:22]([C:25]#[N:26])([CH3:24])[CH3:23])[CH:19]=[CH:18][C:17]=2[O:27][CH:28]([CH3:30])[CH3:29])[C@@H:9]1[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=O)(C)(C)C.C(C(C1C=CC(OC)=C(C=1)CN[C@H]1CCCN[C@H]1C1C=CC=CC=1)C)#N>>[C:25]([C:22]([C:20]1[CH:19]=[CH:18][C:17]([O:27][CH:28]([CH3:30])[CH3:29])=[C:16]([CH:21]=1)[CH2:15][NH:14][C@H:10]1[CH2:11][CH2:12][CH2:13][NH:8][C@H:9]1[C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)([CH3:24])[CH3:23])#[N:26]

Participants

3

Reactant 2

HCID 57058185(2S,3S)-3-(5-(1-cyanoethyl)-2-methoxybenzyl)amino-2-phenylpiperidineHCID 57255311(2S,3S)-1-tert-Butoxycarbonyl-3-(5-(1-cyano-1-methylethyl)-2-isopropoxybenzyl)amino-2-phenylpiperidine

Product 1

HCID 57244318(2S,3S)-3-(5-(1-Cyano-1-methylethyl)-2-isopropoxybenzyl)amino-2-phenylpiperidine

Procedure

This compound was prepared from Compound 42 in the same manner of Compound 19.

Sources & evidence

ORD record
ord-71167b67d8974de983c7ef65d9bb1c38
Source dataset
uspto-grants-1998_08
Patent number
US05789423

Reaction notes

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