Hydrochloride methanol → (2S,3S)-3-[5-(1,1-Dimethyl-2-butynyl)-2-methoxybenzyl]amino-2-phenylpiperidine Dihydrochloride

Participants

Reaction Steps

To a solution of Compound 56 (73 mg, 0.15 mmol) in AcOEt (6 ml) was added an excess amount of 10% HCl-MeOH (3 ml), and stirred for 18 h. After the solvent was evaporated in vacuo, the residual solid was recrystallized from MeOH-ether to give Compound 57 (48 mg, 78%) as a white solid.

Provenance & Evidence