HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-1,2,4-Triazole → 1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloro-1-(2,4-difluorophenyl)ethanone | HCID 588083 | — |
| Reactant | 4-(2,4-Difluorophenyl)thiazole | HCID 10750658 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol | HCID 9910022 | — |
Reaction Steps
2-Chloro-2',4'-difluoroacetophenone is added to 4-(2,4-difluorophenyl)thiazole in the presence of n-butyllithium. After subjecting the reaction product to a post treatment, 1,2,4-triazole and sodium hydride are added thereto to obtain 1-(2,4-difluorophenyl)-1-(4-(2,4-difluorophenyl)thiazol-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789429 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-0281f39f5a3b419b87229b9e9899a6dc |
| Source note | uspto-grants-1998_08 |