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Piperonylamine → 6-trifluoromethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Piperonylamine | HCID 2723901 | — |
| 反応物 | 6-(Trifluoromethyl)indole | HCID 2777523 | — |
| 生成物 | 6-trifluoromethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 11242561 | — |
反応手順
The title compound was prepared in a fashion similar to that described in Preparation 30 from 6-trifluoromethylindole (4.0 g, 22 mmol) and 4-piperidone hydrochloride hydrate (6.6 g, 43 mmol). The product was isolated as a white solid. Yield 3.7 g (64%). mp °C. FDMS m/e=266 (M+ of free base).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789402 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-e9e73b42e86644df91239306da19abf2 |
| 出典メモ | uspto-grants-1998_08 |