HRID481669

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID87111

6-Chloro-1H-indole

C8H6ClN

HCID2723901

Piperidin-4-one--hydrogen chloride--water (1/1/1)

C5H12ClNO2

PRODUCTS

生成物

HCID10059854

6-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole

C13H13ClN2

PROCEDURE

实验过程

The title compound was prepared in a fashion similar to that described in Preparation 30 from 6-chloroindole (4.0 g, 26 mmol) and 4-piperidone hydrochloride hydrate (8.0 g, 52 mmol). The product was isolated as a yellow solid. Yield 3.7 g (61%). mp 181°-185° C. FDMS m/e=234 (M+ of free base).

WORKUP

后处理

customThe product was isolated as a yellow solid