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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 481672Generated: October 25, 2026

Potassium Carbonate → 3-[4-(5-Chloro-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane

https://huagongshe.com/reaction/481672

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant5-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoleHCID 3050532—
Reactant4-(3-chloropropoxy)-1H-indoleHCID 11694169—
Product3-[4-(5-Chloro-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propaneHCID 21268298—

Reaction Steps

The title compound was prepared in a fashion similar to that described in Example 192 from 5-chloro-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.50 g, 2.2 mmol), 1-chloro-3-(1H-indole-4-oxy)propane (0.45 g, 2.2 mmol) and potassium carbonate (0.35 g, 2.5 mmol). The product was isolated as a white foam. Yield 220 mg (25%). mp 198°-202° C. FDMS m/e=406 (M+ of free base).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05789402
Source datasetuspto-grants-1998_08
ORD IDord-c98306152dd04477b785b56f5052ca79
Source noteuspto-grants-1998_08