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Potassium Carbonate → 3-[4-(6-Trifluoromethyl-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-trifluoromethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole | HCID 11242561 | — |
| 反応物 | 4-(3-chloropropoxy)-1H-indole | HCID 11694169 | — |
| 生成物 | 3-[4-(6-Trifluoromethyl-3-indolyl)-1,2,3,6-tetrahydropyridin-1-yl]-1-(4-indolyloxy)propane | HCID 21268286 | — |
反応手順
The title compound was prepared in a fashion similar to that described in Example 192 from 6-trifluoromethyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.50 g, 1.9 mmol), 1-chloro-3-(1H-indole-4-oxy)propane (0.39 g, 1.9 mmol) and potassium carbonate (0.29 g, 2.1 mmol). The product was isolated as a white foam. Yield 0.53 g (64%). mp 190°-195° C. FDMS m/e=440 (M+ of free base).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05789402 |
| 出典データセット | uspto-grants-1998_08 |
| ORD ID | ord-39a62dd27ccb41bf9ccf6b2093f57155 |
| 出典メモ | uspto-grants-1998_08 |