(2s)-Glycidyl indol-4-yl ether → HCID 57133432, compound

Participants

Reaction Steps

The title compound was prepared in a fashion similar to that described in Example 193 from 6,7-dichloro-3-(piperidin-4-yl)-1H-indole (0.80 g, 3.0 mmol) and (S)-(+)-4-(oxiranylmethoxy)-1H-indole (0.58 g, 3.1 mmol). The product was isolated as a white solid. Yield 0.64 g (47%). mp 192°-197° C. FDMS m/e=457 (M+ of free base). α[D]589 =+6.46 (c=0.99, methanol/dimethylsulfoxide).

Provenance & Evidence