反应详情

4-Fluoro-3-nitrophenylacetic acid (31.0 g, 0.156 mol) was added to a mixture of concentrated sulfuric acid (1.6 ml) and methanol (160 ml) and the mixture was stirred for 3 days at room temperature. Most of the solvent was removed in vacuo and the residue was partitioned between diethyl ether and water. The organic phase was washed with saturated aqueous sodium bicarbonate solution and brine, dried over anhydrous magnesium sulfate, filtered and the filtrate was evaporated in vacuo to give methyl 4-fluoro-3-nitrophenylacetate (27.2 g) as a yellow oil.

1. customMost of the solvent was removed in vacuo
2. customthe residue was partitioned between diethyl ether and water
3. washThe organic phase was washed with saturated aqueous sodium bicarbonate solution and brine
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationfiltered
6. customthe filtrate was evaporated in vacuo