HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl Acetate → Enalapril Maleate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl Acetate | HCID 8857 | — |
| Edukt | L-Proline | HCID 145742 | — |
| Edukt | N-[1(S)-Ethoxycarbonyl-3-phenylpropyl]-L-alanine | HCID 5702571 | — |
| Produkt | Enalapril Maleate | HCID 5388961 | 77% |
Reaktionsschritte
In ES patent 2,004,804 the preparation of carboxyalkyldipeptides useful as ACE inhibitors is disclosed. N-[1-(S)-ethoxycarbonyl-3-phenylpropyl]-L-alanine is treated with 1,1-carbonyldiimidazole in EtOAc and subsequently with L-proline and enalapril maleate is obtained with a 77% yield.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05789597 |
| Quelldatensatz | uspto-grants-1998_08 |
| ORD ID | ord-144515cf7c904447a446d2e6c12d553b |
| Quellennotiz | uspto-grants-1998_08 |