HRID48176

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID196

Hexanedioic acid

C6H10O4

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：Nc1ccccc1C(Nc1ccccn1)C(c1ccccn1)C(O)c1ccccc1

HCID15411858

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CCCCC(=O)Nc1ccccc1C(Nc1ccccn1)C(c1ccccn1)C(O)c1ccccc1

HCID22742197

未命名化合物

PROCEDURE

实验过程

Prepared from 1.5 g of 3-(2-aminophenyl)-1-phenyl-2-pyridin-2-yl-3-(pyridin-2-ylamino)propan-1-ol, 3.4 g of hexanedioic acid, 1.04 g of dicyclohexylcarbodiimide and 640 mg of benzotriazol-1-ol, analogously to example II f) Product _of molecular weight 524.6 (C31H32N4O4); MS (ESI+): 525 (M+H+): (ESI−): 523 (M−H+)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d843cd0da3e94fd9922673e5b7059e1a
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06703386B2
来源说明: uspto-grants-2004_03

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]([NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1)[CH:9]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)[CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[OH:11].[C:31](O)(=[O:39])[CH2:32][CH2:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37].C1(N=C=NC2CCCCC2)CCCCC1.N1(O)C2C=CC=CC=2N=N1>>[OH:11][CH:10]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[CH:9]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1)[CH:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[NH:1][C:31]([CH2:32][CH2:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:39])[NH:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=1