Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 5,6,7,9-Tetrahydro-7-iodo-8H-pyrido[2,3-b]azepin-8-one | HCID 19067074 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 19067073 | HCID 19067073 | 94.9% |
Reaction Steps
To 333 mg of the intermediate obtained in Step G in 6 mL of dimethylformamide (DMF) was added 600 mg of sodium azide. The mixture was stirred at 20° C. 20 h before addition of water and extraction with dichloromethane. The extracts were combined and dried over sodium sulfate. Evaporation of the solvent gave 223 mg of the product characterized by its NMR and mass spectra.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05789587 |
|---|
| Source dataset | uspto-grants-1998_08 |
|---|
| ORD ID | ord-9c8fea675a4c426d9124058290234526 |
|---|
| Source note | uspto-grants-1998_08 |
|---|
