HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,5,6,7-Tetrahydro-4H-indol-4-one → 1,5,6,7-Tetrahydro-indol-4-one oxime
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,5,6,7-Tetrahydro-4H-indol-4-one | HCID 280229 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1,5,6,7-Tetrahydro-indol-4-one oxime | HCID 915677 | — |
Reaction Steps
A solution of 6.08 g of sodium acetate, 5.15 g of hydroxylamine hydrochloride, and 5.25 g of 4-keto-4,5,6,7-tetrahydro indole in 12 mL of water and 36 mL of ethanol was heated at 50° C. for 3 hr, quenched in water, extracted with ethyl acetate and dried over magnesium sulfate. The solvents were removed in vacuo to give a mixture of oxime isomers which was characterized by NMR and Mass spectroscopy.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05789587 |
| Source dataset | uspto-grants-1998_08 |
| ORD ID | ord-af4ae2cf1e3246a0ae83c89085e61ea9 |
| Source note | uspto-grants-1998_08 |