Hydrochloric Acid → HCID 11443388, compound

Participants

Reaction Steps

To 23.6 g (0.094 mol) of 2-benzyloxy-7-hydroxynaphthalene and 25.6 g (0.19 mol) of cupric chloride was added 600 ml of methanol, and 56.32 g (0.77 mol) of t-butylamine and 200 ml of methanol were added thereto dropwise over a period of 1.5 hours, followed by stirring for 20 hours. The reaction mixture was cooled with an ice bath, and 200 ml of a 6N hydrochloric acid aqueous solution was added thereto dropwise. The reaction mixture was concentrated with an evaporator. Ethyl acetate was added to the residue, followed by liquid-liquid separation. The organic layer was washed with a saturated sodium chloride aqueous solution, and the solvent was removed by evaporation. The residue was recrystallized from toluene-cyclohexane to yield 20 g (85%) of the title compound.

Provenance & Evidence