HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(4-Acetylaminophenyl)-1,2-Dihydro-6-Methylthiophthalazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 1-(4-Acetylaminophenyl)-7-Methylthiophthalazine | HCID 9944490 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-(4-Acetylaminophenyl)-1,2-Dihydro-6-Methylthiophthalazine | HCID 12986174 | 74.2% |
Reaction Steps
To a solution of the phthalazine 7 (130 mg, 0.42 mmol) in acetic acid (7 mL) was added NaBH3CN in portions. After stirring for 15 min, water was added. The aqueous phase was neutralized by NaHCO3, and then extracted with DCM. The combined organic phase was dried over Na2SO4. Removal of the solvent afforded the product (97 mg, 74%) which can be used directly for next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06703390B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-9a7efb84837a45f191150388858196ea |
| Source note | uspto-grants-2004_03 |