反应详情

The title compound was prepared as described in General Method 1 using 25 mmol of methyl acetoacetate, 27.5 mmol of NaH 60% dispersion in oil, 26.25 mmol of 1.6M n-butyl lithium in hexane, 25 mmol of heptanophenone and 70 mL of tetrahydrofuran. Upon concentrating the reaction, a solid precipitated out which was triturated with ether and filtered (m.p. 119°-120.5° C.). 1H NMR (CDCl3) δ0.84 (t, 3H), 1.1-1.4 (m, 8H), 1.9-2.0 (m, 2H), 2.89 (d, 1H), 2.93 (d, 1H), 3.24 (d, 1H), 3.35 (d, 1H), 7.2-7.5 (m, 5H).

1. concentrationUpon concentrating
2. customthe reaction
3. customa solid precipitated out which
4. customwas triturated with ether
5. filtrationfiltered (m.p. 119°-120.5° C.)