反应详情

The title compound was prepared as described in General Method 6 from 1.5 mmol of 3-bromo-5,6-dihydro-4-hydroxy-6-(3-methylbutyl)-6-phenyl-2H-pyran-2-one (prepared in example CCC), 1.6 mmol of benzenethiol, and 1.6 mmol of piperidine in 20 mL of dichloromethane. The crude product was chromatographed on silica gel, eluting first with chloroform and then with 5% methanol in chloroform, to give the title compound, (m.p. 154°-155° C.). 1H NMR (DMSO-d6) δ0.80 (m, 6H), 0.97 (m, 1H), 1.16 (m, 2H), 1.42 (m, 1H), 1.91 (m, 2H), 3.40 (2H+H2O), 6.45 (m, 2H), 6.93 (m, 3H), 7.37 (m, 5H).

1. customThe title compound was prepared
2. customThe crude product was chromatographed on silica gel
3. washeluting first with chloroform