反应详情

The title compound was prepared as described in General Method 6 from 1.5 mmol of 3-bromo-5,6-dihydro-4-hydroxy-6,6-diphenyl-2H-pyran-2-one (prepared in example AAA), 1.6 mmol of 2-methoxybenzenethiol, and 1.6 mmol of piperidine in 25 mL of dichloromethane. The product was chromatographed on silica gel, eluting first with chloroform and then with 5% methanol in chloroform, to give the title compound (m.p. 170°-172° C. dec.). 1H NMR (DMSO-d6) δ3.76 (bs, 5H), 5.44 (dd, 1H), 6.26 (t, 1H), 6.85 (m, 1H), 6.91 (t, 1H), 7.34-7.50 (m, 10H).

1. customThe title compound was prepared
2. customThe product was chromatographed on silica gel
3. washeluting first with chloroform