1,2-Dimethyl-10-(3-aminopropyl)phenothiazine → 1,2-Dimethyl-10-(3-aminopropyl)phenothiazine-5,5-dioxide

Participants

Reaction Steps

To 20 ml of a solution of 870 mg of 1,2-dimethyl-10-(3-aminopropyl)phenothiazine obtained in Example 1 in methanol was added an aqueous solution of 3.7 g of oxone in 20 ml of water and the resulting mixture was stirred at room temperature for 30 min. After evaporating the solvent, the residue was purified by silica gel column chromatography to give 200 mg of the title compound.

Provenance & Evidence