2-Amino-5-bromopyridine → HCID 86753004, compound

Participants

Reaction Steps

78.0 ml (0.64 mol) of trichloroethyl chloroformate are added dropwise at boiling heat to a stirred solution of 100 g (0.58 mol) of 2-amino-5-bromopyridine in 400 ml of 1,2-dichloroethane. After the addition the mixture is refluxed for 2 h, then it may be cooled to room temperature. The resulting precipitate is removed by filtration, washed well with 100 ml of 1,2-dichloroethane and dried over sodium hydroxide in a high vacuum. 98.3 g (72%) of the title compound are obtained as a yellow solid.

Provenance & Evidence