Dimethylformamide → HCID 70195540, compound

Participants

Reaction Steps

100 mg (0.37 mmol) of the compound from Example XXVIII (free base; prepared by dissolving in water, NH3(aq) addition to pH 11, extraction with CH2Cl2, drying over MgSO4 and concentrating) are initially introduced into 1 ml of DMF under argon and 200 mg (1.11 mmol) of 2-(2-nitro-prop-1-en-1-yl-amino)-pyridine are added and the mixture is stirred overnight. It is treated with water, extracted 3× with ethyl acetate, and the organic phase is washed with satd. NaCl solution and dried over MgSO4. It is concentrated and the residue is purified by column chromatography on silica gel (eluent CH2Cl2 :MeOH=100:5). 126 mg (96% of theory) of the title compound are obtained.

Provenance & Evidence